Search | Virtual Health Library

1.

Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer.

Raghavan, Srivatsan; Winter, Peter S; Navia, Andrew W; Williams, Hannah L; DenAdel, Alan; Lowder, Kristen E; Galvez-Reyes, Jennyfer; Kalekar, Radha L; Mulugeta, Nolawit; Kapner, Kevin S; Raghavan, Manisha S; Borah, Ashir A; Liu, Nuo; Väyrynen, Sara A; Costa, Andressa Dias; Ng, Raymond W S; Wang, Junning; Hill, Emma K; Ragon, Dorisanne Y; Brais, Lauren K; Jaeger, Alex M; Spurr, Liam F; Li, Yvonne Y; Cherniack, Andrew D; Booker, Matthew A; Cohen, Elizabeth F; Tolstorukov, Michael Y; Wakiro, Isaac; Rotem, Asaf; Johnson, Bruce E; McFarland, James M; Sicinska, Ewa T; Jacks, Tyler E; Sullivan, Ryan J; Shapiro, Geoffrey I; Clancy, Thomas E; Perez, Kimberly; Rubinson, Douglas A; Ng, Kimmie; Cleary, James M; Crawford, Lorin; Manalis, Scott R; Nowak, Jonathan A; Wolpin, Brian M; Hahn, William C; Aguirre, Andrew J; Shalek, Alex K.

Cell ; 184(25): 6119-6137.e26, 2021 12 09.

Article in English | MEDLINE | ID: mdl-34890551

2.

Biomarker-Guided Development of DNA Repair Inhibitors.

Cleary, James M; Aguirre, Andrew J; Shapiro, Geoffrey I; D'Andrea, Alan D.

Mol Cell ; 78(6): 1070-1085, 2020 06 18.

Article in English | MEDLINE | ID: mdl-32459988

3.

CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress.

Li, Feng; Kozono, David; Deraska, Peter; Branigan, Timothy; Dunn, Connor; Zheng, Xiao-Feng; Parmar, Kalindi; Nguyen, Huy; DeCaprio, James; Shapiro, Geoffrey I; Chowdhury, Dipanjan; D'Andrea, Alan D.

Mol Cell ; 80(3): 410-422.e6, 2020 11 05.

Article in English | MEDLINE | ID: mdl-33108758

4.

Author Correction: HER kinase inhibition in patients with HER2- and HER3-mutant cancers.

Hyman, David M; Piha-Paul, Sarina A; Won, Helen; Rodon, Jordi; Saura, Cristina; Shapiro, Geoffrey I; Juric, Dejan; Quinn, David I; Moreno, Victor; Doger, Bernard; Mayer, Ingrid A; Boni, Valentina; Calvo, Emiliano; Loi, Sherene; Lockhart, Albert C; Erinjeri, Joseph P; Scaltriti, Maurizio; Ulaner, Gary A; Patel, Juber; Tang, Jiabin; Beer, Hannah; Selcuklu, S Duygu; Hanrahan, Aphrothiti J; Bouvier, Nancy; Melcer, Myra; Murali, Rajmohan; Schram, Alison M; Smyth, Lillian M; Jhaveri, Komal; Li, Bob T; Drilon, Alexander; Harding, James J; Iyer, Gopa; Taylor, Barry S; Berger, Michael F; Cutler, Richard E; Xu, Feng; Butturini, Anna; Eli, Lisa D; Mann, Grace; Farrell, Cynthia; Lalani, Alshad S; Bryce, Richard P; Arteaga, Carlos L; Meric-Bernstam, Funda; Baselga, José; Solit, David B.

Nature ; 566(7745): E11-E12, 2019 02.

Article in English | MEDLINE | ID: mdl-30755741

5.

Targeting HER2-mutant metastatic cervical cancer with neratinib: Final results from the phase 2 SUMMIT basket trial.

Friedman, Claire F; D'Souza, Anishka; Bello Roufai, Diana; Tinker, Anna V; de Miguel, Maria; Gambardella, Valentina; Goldman, Jonathan; Loi, Sherene; Melisko, Michelle E; Oaknin, Ana; Spanggaard, Iben; Shapiro, Geoffrey I; ElNaggar, Adam C; Panni, Stefano; Ravichandran, Vignesh; Frazier, Aimee L; DiPrimeo, Daniel; Eli, Lisa D; Solit, David B.

Gynecol Oncol ; 181: 162-169, 2024 Feb.

Article in English | MEDLINE | ID: mdl-38211393

6.

HER kinase inhibition in patients with HER2- and HER3-mutant cancers.

Hyman, David M; Piha-Paul, Sarina A; Won, Helen; Rodon, Jordi; Saura, Cristina; Shapiro, Geoffrey I; Juric, Dejan; Quinn, David I; Moreno, Victor; Doger, Bernard; Mayer, Ingrid A; Boni, Valentina; Calvo, Emiliano; Loi, Sherene; Lockhart, Albert C; Erinjeri, Joseph P; Scaltriti, Maurizio; Ulaner, Gary A; Patel, Juber; Tang, Jiabin; Beer, Hannah; Selcuklu, S Duygu; Hanrahan, Aphrothiti J; Bouvier, Nancy; Melcer, Myra; Murali, Rajmohan; Schram, Alison M; Smyth, Lillian M; Jhaveri, Komal; Li, Bob T; Drilon, Alexander; Harding, James J; Iyer, Gopa; Taylor, Barry S; Berger, Michael F; Cutler, Richard E; Xu, Feng; Butturini, Anna; Eli, Lisa D; Mann, Grace; Farrell, Cynthia; Lalani, Alshad S; Bryce, Richard P; Arteaga, Carlos L; Meric-Bernstam, Funda; Baselga, José; Solit, David B.

Nature ; 554(7691): 189-194, 2018 02 08.

Article in English | MEDLINE | ID: mdl-29420467

7.

Dose-escalation trial of combination dabrafenib, trametinib, and AT13387 in patients with BRAF-mutant solid tumors.

Mooradian, Meghan J; Cleary, James M; Giobbie-Hurder, Anita; Darville, Lancia N F; Parikh, Aparna; Buchbinder, Elizabeth I; Cohen, Justine V; Lawrence, Donald P; Shapiro, Geoffrey I; Keer, Harold; Chen, Helen X; Ivy, Susan Percy; Smalley, Keiran S M; Koomen, John M; Sullivan, Ryan J.

Cancer ; 129(12): 1904-1918, 2023 06 15.

Article in English | MEDLINE | ID: mdl-37042037

8.

A Phase 1B open-label study of gedatolisib (PF-05212384) in combination with other anti-tumour agents for patients with advanced solid tumours and triple-negative breast cancer.

Curigliano, Giuseppe; Shapiro, Geoffrey I; Kristeleit, Rebecca S; Abdul Razak, Albiruni R; Leong, Stephen; Alsina, Maria; Giordano, Antonio; Gelmon, Karen A; Stringer-Reasor, Erica; Vaishampayan, Ulka N; Middleton, Mark; Olszanski, Anthony J; Rugo, Hope S; Kern, Kenneth A; Pathan, Nuzhat; Perea, Rachelle; Pierce, Kristen J; Mutka, Sarah C; Wainberg, Zev A.

Br J Cancer ; 128(1): 30-41, 2023 01.

Article in English | MEDLINE | ID: mdl-36335217

9.

KRAS^G12C Inhibition with Sotorasib in Advanced Solid Tumors.

Hong, David S; Fakih, Marwan G; Strickler, John H; Desai, Jayesh; Durm, Gregory A; Shapiro, Geoffrey I; Falchook, Gerald S; Price, Timothy J; Sacher, Adrian; Denlinger, Crystal S; Bang, Yung-Jue; Dy, Grace K; Krauss, John C; Kuboki, Yasutoshi; Kuo, James C; Coveler, Andrew L; Park, Keunchil; Kim, Tae Won; Barlesi, Fabrice; Munster, Pamela N; Ramalingam, Suresh S; Burns, Timothy F; Meric-Bernstam, Funda; Henary, Haby; Ngang, Jude; Ngarmchamnanrith, Gataree; Kim, June; Houk, Brett E; Canon, Jude; Lipford, J Russell; Friberg, Gregory; Lito, Piro; Govindan, Ramaswamy; Li, Bob T.

N Engl J Med ; 383(13): 1207-1217, 2020 09 24.

Article in English | MEDLINE | ID: mdl-32955176

10.

Combining PARP Inhibition and Immunotherapy in BRCA-Associated Cancers.

Shapiro, Geoffrey I; Barry, Suzanne M.

Cancer Treat Res ; 186: 207-221, 2023.

Article in English | MEDLINE | ID: mdl-37978138

11.

Safety, pharmacokinetic, pharmacodynamic and clinical activity of molibresib for the treatment of nuclear protein in testis carcinoma and other cancers: Results of a Phase I/II open-label, dose escalation study.

Cousin, Sophie; Blay, Jean-Yves; Garcia, Irene Braña; de Bono, Johann S; Le Tourneau, Christophe; Moreno, Victor; Trigo, Jose; Hann, Christine L; Azad, Arun A; Im, Seock-Ah; Cassier, Philippe A; French, Christopher A; Italiano, Antoine; Keedy, Vicki L; Plummer, Ruth; Sablin, Marie-Paule; Hemming, Matthew L; Ferron-Brady, Geraldine; Wyce, Anastasia; Khaled, Ahmed; Datta, Antara; Foley, Shawn W; McCabe, Michael T; Wu, Yuehui; Horner, Thierry; Kremer, Brandon E; Dhar, Arindam; O'Dwyer, Peter J; Shapiro, Geoffrey I; Piha-Paul, Sarina A.

Int J Cancer ; 150(6): 993-1006, 2022 03 15.

Article in English | MEDLINE | ID: mdl-34724226

12.

Combined PARP and HSP90 inhibition: preclinical and Phase 1 evaluation in patients with advanced solid tumours.

Konstantinopoulos, Panagiotis A; Cheng, Su-Chun; Supko, Jeffrey G; Polak, Madeline; Wahner-Hendrickson, Andrea E; Ivy, S Percy; Bowes, Brittany; Sawyer, Hannah; Basada, Patrice; Hayes, Martin; Curtis, Jennifer; Horowitz, Neil; Wright, Alexi A; Campos, Susana M; Ivanova, Elena V; Paweletz, Cloud P; Palakurthi, Sangeetha; Liu, Joyce F; D'Andrea, Alan D; Gokhale, Prafulla C; Chowdhury, Dipanjan; Matulonis, Ursula A; Shapiro, Geoffrey I.

Br J Cancer ; 126(7): 1027-1036, 2022 04.

Article in English | MEDLINE | ID: mdl-34887522

13.

CSF1 receptor inhibition of tenosynovial giant cell tumor using novel disease-specific MRI measures of tumor burden.

Peterfy, Charles; Chen, Yan; Countryman, Peter; Chmielowski, Bartosz; Anthony, Stephen P; Healey, John H; Wainberg, Zev A; Cohn, Allen L; Shapiro, Geoffrey I; Keedy, Vicki L; Singh, Arun; Puzanov, Igor; Wagner, Andrew J; Qian, Meng; Sterba, Mike; Hsu, Henry H; Tong-Starksen, Sandra; Tap, William D.

Future Oncol ; 18(12): 1449-1459, 2022 Apr.

Article in English | MEDLINE | ID: mdl-35040698

14.

Phase 1 study of the ATR inhibitor berzosertib in combination with cisplatin in patients with advanced solid tumours.

Shapiro, Geoffrey I; Wesolowski, Robert; Devoe, Craig; Lord, Simon; Pollard, John; Hendriks, Bart S; Falk, Martin; Diaz-Padilla, Ivan; Plummer, Ruth; Yap, Timothy A.

Br J Cancer ; 125(4): 520-527, 2021 08.

Article in English | MEDLINE | ID: mdl-34040174

15.

Phase 1 study of the ATR inhibitor berzosertib (formerly M6620, VX-970) combined with gemcitabine ± cisplatin in patients with advanced solid tumours.

Middleton, Mark R; Dean, Emma; Evans, Thomas R J; Shapiro, Geoffrey I; Pollard, John; Hendriks, Bart S; Falk, Martin; Diaz-Padilla, Ivan; Plummer, Ruth.

Br J Cancer ; 125(4): 510-519, 2021 08.

Article in English | MEDLINE | ID: mdl-34040175

16.

A Phase 1 study of RO6870810, a novel bromodomain and extra-terminal protein inhibitor, in patients with NUT carcinoma, other solid tumours, or diffuse large B-cell lymphoma.

Shapiro, Geoffrey I; LoRusso, Patricia; Dowlati, Afshin; T Do, Khanh; Jacobson, Caron A; Vaishampayan, Ulka; Weise, Amy; Caimi, Paolo F; Eder, Joseph Paul; French, Christopher A; Labriola-Tompkins, Emily; Boisserie, Frédéric; Pierceall, William E; Zhi, Jianguo; Passe, Sharon; DeMario, Mark; Kornacker, Martin; Armand, Philippe.

Br J Cancer ; 124(4): 744-753, 2021 02.

Article in English | MEDLINE | ID: mdl-33311588

17.

Immune modulating activity of the CHK1 inhibitor prexasertib and anti-PD-L1 antibody LY3300054 in patients with high-grade serous ovarian cancer and other solid tumors.

Do, Khanh T; Manuszak, Claire; Thrash, Emily; Giobbie-Hurder, Anita; Hu, Jiani; Kelland, Sarah; Powers, Allison; de Jonge, Adrienne; Shapiro, Geoffrey I; Severgnini, Mariano.

Cancer Immunol Immunother ; 70(10): 2991-3000, 2021 Oct.

Article in English | MEDLINE | ID: mdl-33745032

18.

Phase 1 dose escalation study of seribantumab (MM-121), an anti-HER3 monoclonal antibody, in patients with advanced solid tumors.

Denlinger, Crystal S; Keedy, Vicki L; Moyo, Victor; MacBeath, Gavin; Shapiro, Geoffrey I.

Invest New Drugs ; 39(6): 1604-1612, 2021 12.

Article in English | MEDLINE | ID: mdl-34250553

19.

A phase Ib open-label dose escalation study of the safety, pharmacokinetics, and pharmacodynamics of cobimetinib (GDC-0973) and ipatasertib (GDC-0068) in patients with locally advanced or metastatic solid tumors.

Shapiro, Geoffrey I; LoRusso, Patricia; Cho, Daniel C; Musib, Luna; Yan, Yibing; Wongchenko, Matthew; Chang, Ilsung; Patel, Premal; Chan, Iris T; Sanabria-Bohorquez, Sandra; Meng, Raymond D; Bendell, Johanna C.

Invest New Drugs ; 39(1): 163-174, 2021 02.

Article in English | MEDLINE | ID: mdl-32737717

20.

Characterization of patients with long-term responses to rucaparib treatment in recurrent ovarian cancer.

Swisher, Elizabeth M; Kristeleit, Rebecca S; Oza, Amit M; Tinker, Anna V; Ray-Coquard, Isabelle; Oaknin, Ana; Coleman, Robert L; Burris, Howard A; Aghajanian, Carol; O'Malley, David M; Leary, Alexandra; Welch, Stephen; Provencher, Diane; Shapiro, Geoffrey I; Chen, Lee-May; Shapira-Frommer, Ronnie; Kaufmann, Scott H; Goble, Sandra; Maloney, Lara; Kwan, Tanya; Lin, Kevin K; McNeish, Iain A.

Gynecol Oncol ; 163(3): 490-497, 2021 12.

Article in English | MEDLINE | ID: mdl-34602290

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